This Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder's Root Cause Rather Than Its Symptoms

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https://www.smithsonianmag.com/smart-news/this-newly-approved-narcolepsy-drug-is-the-first-to-target-the-sleep-disorders-root-cause-rather-than-its-symptoms-180989362/

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narcolepsy14x no texto
“However, experts also stress that there’s still a lot to learn about narcolepsy and the role orexin plays in the brain.”
TermoTradução
Frase de exemploHowever, experts also stress that there’s still a lot to learn about narcolepsy and the role orexin plays in the brain.
drug8x no texto
“For 12 weeks, participants took a high or low dose of the drug or a placebo.”
TermoTradução
Frase de exemploFor 12 weeks, participants took a high or low dose of the drug or a placebo.
orexin8x no texto
“However, experts also stress that there’s still a lot to learn about narcolepsy and the role orexin plays in the brain.”
TermoTradução
Frase de exemploHowever, experts also stress that there’s still a lot to learn about narcolepsy and the role orexin plays in the brain.
disorder5x no texto
“Still, the recent approval is a source of hope for many people who have the sleep disorder.”
TermoTradução
Frase de exemploStill, the recent approval is a source of hope for many people who have the sleep disorder.
treatment5x no texto
“There were no serious adverse events related to treatment.”
TermoTradução
Frase de exemploThere were no serious adverse events related to treatment.
cause4x no texto
“Most individuals with this condition have normal orexin levels, and researchers still aren’t sure about the disorder’s underlying cause.”
TermoTradução
Frase de exemploMost individuals with this condition have normal orexin levels, and researchers still aren’t sure about the disorder’s underlying cause.
chemical4x no texto
“The disease is linked to the death of brain cells that produce orexin, a chemical that plays roles in wakefulness, sleep and muscle tone.”
TermoTradução
Frase de exemploThe disease is linked to the death of brain cells that produce orexin, a chemical that plays roles in wakefulness, sleep and muscle tone.
disease4x no texto
“The disease is linked to the death of brain cells that produce orexin, a chemical that plays roles in wakefulness, sleep and muscle tone.”
TermoTradução
Frase de exemploThe disease is linked to the death of brain cells that produce orexin, a chemical that plays roles in wakefulness, sleep and muscle tone.
cataplexy4x no texto
“They also reported fewer cataplexy episodes.”
TermoTradução
Frase de exemploThey also reported fewer cataplexy episodes.
approved3x no texto
“FG Trade via Getty Images In early August, the Food and Drug Administration (FDA) approved the first drug that targets the root cause of a form of narcolepsy, a chronic brain disorder that causes extreme daytime sleepiness.”
TermoTradução
Frase de exemploFG Trade via Getty Images In early August, the Food and Drug Administration (FDA) approved the first drug that targets the root cause of a form of narcolepsy, a chronic brain disorder that causes extreme daytime sleepiness.
root3x no texto
“FG Trade via Getty Images In early August, the Food and Drug Administration (FDA) approved the first drug that targets the root cause of a form of narcolepsy, a chronic brain disorder that causes extreme daytime sleepiness.”
TermoTradução
Frase de exemploFG Trade via Getty Images In early August, the Food and Drug Administration (FDA) approved the first drug that targets the root cause of a form of narcolepsy, a chronic brain disorder that causes extreme daytime sleepiness.
symptoms3x no texto
“But they only addressed symptoms of the disease.”
TermoTradução
Frase de exemploBut they only addressed symptoms of the disease.
renew3x no texto
“This Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder's Root Cause Rather Than Its Symptoms Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.”
TermoTradução
Frase de exemploThis Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder's Root Cause Rather Than Its Symptoms Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.
loss3x no texto
“The loss leads to excessive daytime sleepiness, sleep paralysis, hallucinations when falling asleep and waking up, disrupted nighttime sleep and cataplexy—sudden muscle weakness while fully awake.”
TermoTradução
Frase de exemploThe loss leads to excessive daytime sleepiness, sleep paralysis, hallucinations when falling asleep and waking up, disrupted nighttime sleep and cataplexy—sudden muscle weakness while fully awake.
cycle3x no texto
“Now, thanks to Orzeyful, Chapman can follow a standard sleep-wake cycle.”
TermoTradução
Frase de exemploNow, thanks to Orzeyful, Chapman can follow a standard sleep-wake cycle.
daytime3x no texto
“Quick fact: Another main type of narcolepsy Some people with narcolepsy have type 2 , which causes daytime sleepiness but no cataplexy.”
TermoTradução
Frase de exemploQuick fact: Another main type of narcolepsy Some people with narcolepsy have type 2 , which causes daytime sleepiness but no cataplexy.
sleepiness3x no texto
“Quick fact: Another main type of narcolepsy Some people with narcolepsy have type 2 , which causes daytime sleepiness but no cataplexy.”
TermoTradução
Frase de exemploQuick fact: Another main type of narcolepsy Some people with narcolepsy have type 2 , which causes daytime sleepiness but no cataplexy.
approval3x no texto
“The approval comes after a pair of late-stage clinical trials demonstrated Orzeyful’s efficacy and safety in 273 adults with narcolepsy type 1.”
TermoTradução
Frase de exemploThe approval comes after a pair of late-stage clinical trials demonstrated Orzeyful’s efficacy and safety in 273 adults with narcolepsy type 1.
president3x no texto
““It’s just a little bit less than 30 years ago that the orexin pathway was discovered,” says Julie Flygare , an Orzeyful trial participant and president and CEO of the nonprofit Project Sleep , to Forbes .”
TermoTradução
Frase de exemplo“It’s just a little bit less than 30 years ago that the orexin pathway was discovered,” says Julie Flygare , an Orzeyful trial participant and president and CEO of the nonprofit Project Sleep , to Forbes .
statement3x no texto
“With orexin emerging as a powerful therapeutic pathway, Takeda is unlocking the potential of this new class of medicine for patients across a range of disorders,” says Andy Plump , the company’s president of research and development, in the statement.”
TermoTradução
Frase de exemploWith orexin emerging as a powerful therapeutic pathway, Takeda is unlocking the potential of this new class of medicine for patients across a range of disorders,” says Andy Plump , the company’s president of research and development, in the statement.
drugs3x no texto
“Giving attention only to orexin-mimicking drugs would be “a mistake,” he adds, and future therapies might involve combining medications.”
TermoTradução
Frase de exemploGiving attention only to orexin-mimicking drugs would be “a mistake,” he adds, and future therapies might involve combining medications.
newly2x no texto
“This Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder’s Root Cause Rather Than Its Symptoms The Food and Drug Administration just greenlit a medication called Orzeyful for the treatment of narcolepsy type 1 in adults.”
TermoTradução
Frase de exemploThis Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder’s Root Cause Rather Than Its Symptoms The Food and Drug Administration just greenlit a medication called Orzeyful for the treatment of narcolepsy type 1 in adults.
target2x no texto
“This Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder’s Root Cause Rather Than Its Symptoms The Food and Drug Administration just greenlit a medication called Orzeyful for the treatment of narcolepsy type 1 in adults.”
TermoTradução
Frase de exemploThis Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder’s Root Cause Rather Than Its Symptoms The Food and Drug Administration just greenlit a medication called Orzeyful for the treatment of narcolepsy type 1 in adults.
rather2x no texto
“This Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder’s Root Cause Rather Than Its Symptoms The Food and Drug Administration just greenlit a medication called Orzeyful for the treatment of narcolepsy type 1 in adults.”
TermoTradução
Frase de exemploThis Newly Approved Narcolepsy Drug Is the First to Target the Sleep Disorder’s Root Cause Rather Than Its Symptoms The Food and Drug Administration just greenlit a medication called Orzeyful for the treatment of narcolepsy type 1 in adults.