Experimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial

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https://www.smithsonianmag.com/smart-news/experimental-alzheimers-drug-that-fights-a-tough-to-target-protein-shows-promise-at-slowing-cognitive-decline-in-a-clinical-trial-180989177/

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smithsonian14x no texto
“Experimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.”
TermoTradução
Frase de exemploExperimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.
drug13x no texto
“The drug, called diranersen, was developed by Biogen, a Massachusetts-based biotech company.”
TermoTradução
Frase de exemploThe drug, called diranersen, was developed by Biogen, a Massachusetts-based biotech company.
tau13x no texto
“It works by attaching itself to genetic instructions for making tau, forcing the brain to produce less of the protein.”
TermoTradução
Frase de exemploIt works by attaching itself to genetic instructions for making tau, forcing the brain to produce less of the protein.
cognitive10x no texto
“They were tracked for 18 months and given several cognitive tests.”
TermoTradução
Frase de exemploThey were tracked for 18 months and given several cognitive tests.
alzheimer9x no texto
“The recent trial involved more than 400 patients with early-stage Alzheimer’s split into four groups.”
TermoTradução
Frase de exemploThe recent trial involved more than 400 patients with early-stage Alzheimer’s split into four groups.
trial8x no texto
“The recent trial involved more than 400 patients with early-stage Alzheimer’s split into four groups.”
TermoTradução
Frase de exemploThe recent trial involved more than 400 patients with early-stage Alzheimer’s split into four groups.
protein7x no texto
“It works by attaching itself to genetic instructions for making tau, forcing the brain to produce less of the protein.”
TermoTradução
Frase de exemploIt works by attaching itself to genetic instructions for making tau, forcing the brain to produce less of the protein.
tangles6x no texto
“Brain imaging of 131 participants also showed decreases in tau tangles relative to baseline across all doses.”
TermoTradução
Frase de exemploBrain imaging of 131 participants also showed decreases in tau tangles relative to baseline across all doses.
drugs6x no texto
“She notes that other trials are studying combinations of different anti-tau and anti-amyloid drugs.”
TermoTradução
Frase de exemploShe notes that other trials are studying combinations of different anti-tau and anti-amyloid drugs.
received6x no texto
“And some participants who received higher doses suffered from a state of confusion for up to one week following injection.”
TermoTradução
Frase de exemploAnd some participants who received higher doses suffered from a state of confusion for up to one week following injection.
experimental5x no texto
“Meanwhile, many experimental treatments targeting tau have failed, despite research suggesting that tau tangles are a stronger predictor than amyloid of brain deterioration.”
TermoTradução
Frase de exemploMeanwhile, many experimental treatments targeting tau have failed, despite research suggesting that tau tangles are a stronger predictor than amyloid of brain deterioration.
decline5x no texto
“The middle-dose group’s cognitive decline slowed by 14 percent based on that test, and the highest-dose group’s slowed by 9 percent.”
TermoTradução
Frase de exemploThe middle-dose group’s cognitive decline slowed by 14 percent based on that test, and the highest-dose group’s slowed by 9 percent.
amyloid5x no texto
“She notes that other trials are studying combinations of different anti-tau and anti-amyloid drugs.”
TermoTradução
Frase de exemploShe notes that other trials are studying combinations of different anti-tau and anti-amyloid drugs.
disease5x no texto
“Accumulations of these tau tangles and sticky clumps of the protein amyloid beta are the neurodegenerative disease’s defining features.”
TermoTradução
Frase de exemploAccumulations of these tau tangles and sticky clumps of the protein amyloid beta are the neurodegenerative disease’s defining features.
treatment5x no texto
“In all three treatment groups, the drug lowered tau levels in brain and spinal fluid by 50 to 65 percent compared to the participants’ starting baseline.”
TermoTradução
Frase de exemploIn all three treatment groups, the drug lowered tau levels in brain and spinal fluid by 50 to 65 percent compared to the participants’ starting baseline.
clinical4x no texto
“The company now plans to test diranersen in a late-phase clinical trial to see how it fares with a larger group of participants.”
TermoTradução
Frase de exemploThe company now plans to test diranersen in a late-phase clinical trial to see how it fares with a larger group of participants.
subscribe4x no texto
“Experimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.”
TermoTradução
Frase de exemploExperimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.
london4x no texto
“Rob Howard , a psychiatrist at University College London who wasn’t involved in the study, explains to R.J.”
TermoTradução
Frase de exemploRob Howard , a psychiatrist at University College London who wasn’t involved in the study, explains to R.J.
says4x no texto
““We are seeing the entire movement of thinking about these different targets and how [we can] start putting tau together with amyloid,” Snyder says.”
TermoTradução
Frase de exemplo“We are seeing the entire movement of thinking about these different targets and how [we can] start putting tau together with amyloid,” Snyder says.
months4x no texto
“They were tracked for 18 months and given several cognitive tests.”
TermoTradução
Frase de exemploThey were tracked for 18 months and given several cognitive tests.
percent4x no texto
“The middle-dose group’s cognitive decline slowed by 14 percent based on that test, and the highest-dose group’s slowed by 9 percent.”
TermoTradução
Frase de exemploThe middle-dose group’s cognitive decline slowed by 14 percent based on that test, and the highest-dose group’s slowed by 9 percent.
participants4x no texto
“Brain imaging of 131 participants also showed decreases in tau tangles relative to baseline across all doses.”
TermoTradução
Frase de exemploBrain imaging of 131 participants also showed decreases in tau tangles relative to baseline across all doses.
slowing3x no texto
“In the trial, the lowest-dose group experienced the greatest slowing of cognitive decline—by 26 percent in one test—and the smallest decrease in tau levels.”
TermoTradução
Frase de exemploIn the trial, the lowest-dose group experienced the greatest slowing of cognitive decline—by 26 percent in one test—and the smallest decrease in tau levels.
newsletters3x no texto
“Experimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.”
TermoTradução
Frase de exemploExperimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.
renew3x no texto
“Experimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.”
TermoTradução
Frase de exemploExperimental Alzheimer's Drug That Fights a Tough-to-Target Protein Shows Promise at Slowing Cognitive Decline in a Clinical Trial Skip to main content Search Shop Newsletters Renew Give a Gift Subscribe Membership i Subscribe Give a Gift Renew Sections Smart News History Science Innovation Arts & Culture Travel At the Smithsonian More from Smithsonian magazine Newsletters Photo Contest Podcast Videos Our Partners Smithsonian Store Smithsonian Journeys Subscribe to Smithsonian magazine and get a FREE tote.
sara3x no texto
“Here Are Five Nominees Worth Visiting Now July 23, 2026 Sara Hashemi | Read More Sara Hashemi is a science writer and fact-checker currently based in New York City.”
TermoTradução
Frase de exemploHere Are Five Nominees Worth Visiting Now July 23, 2026 Sara Hashemi | Read More Sara Hashemi is a science writer and fact-checker currently based in New York City.
hashemi3x no texto
“Here Are Five Nominees Worth Visiting Now July 23, 2026 Sara Hashemi | Read More Sara Hashemi is a science writer and fact-checker currently based in New York City.”
TermoTradução
Frase de exemploHere Are Five Nominees Worth Visiting Now July 23, 2026 Sara Hashemi | Read More Sara Hashemi is a science writer and fact-checker currently based in New York City.
researchers3x no texto
“But the drug defied one of the researchers’ main expectations: that cognitive outcomes would strengthen with dose.”
TermoTradução
Frase de exemploBut the drug defied one of the researchers’ main expectations: that cognitive outcomes would strengthen with dose.
recent3x no texto
“The recent trial involved more than 400 patients with early-stage Alzheimer’s split into four groups.”
TermoTradução
Frase de exemploThe recent trial involved more than 400 patients with early-stage Alzheimer’s split into four groups.
approved3x no texto
“In recent years, two drugs that clear amyloid plaques have been approved by the Food and Drug Administration—the first new Alzheimer’s therapies in about two decades.”
TermoTradução
Frase de exemploIn recent years, two drugs that clear amyloid plaques have been approved by the Food and Drug Administration—the first new Alzheimer’s therapies in about two decades.